Built on BactPac™

A first-in-class pipeline

We are developing a first-in-class pipeline addressing three therapeutic areas: cancer, respiratory, and genetic diseases

Targeting severe diseases faces the challenge of finding truly effective delivery methods. SiVEC steps in as the knowledgeable guide, offering a revolutionary drug delivery system called BactPac. With this, medicines can be directed precisely where they're needed most. SiVEC invites biotech and pharma companies to join them in this mission, promising a future where treatments are safer, more effective, and can conquer even the toughest diseases.

Cancer

SVC-KRAb™

Using the BactPac platform, SiVEC has developed SVC-KRAb™, a first-in-class live biotherapeutic cancer therapy targeting oncogenic KRAS (pan-mutant KRAS therapeutic). SVC-KRAb™ is widely applicable to a broad patient population due to its recalcitrance to specific KRAS mutations, revolutionizing the treatment of KRAS-mutant cancer. We have engineered our bacteria to express and deliver a single-domain antibody (nanobody) that broadly targets mutant KRAS. This cancer therapeutic targets KRAS mutations in pancreatic ductal adenocarcinoma (PDAC), colorectal cancer (CRC), and non-small cell lung cancer (NSCLC), among others.

ADVANTAGES of SiVEC-KRAb™

• BactPac produces the cancer-targeting therapeutic during manufacturing

• BactPac targets and infiltrates tumors

• BactPac delivers its cargo intracellularly to inhibiting cell autonomous signaling

Respiratory

SiVEC-IAV™

Individuals, especially those at high risk, dread the flu season and the hazard it poses. Enter SiVEC with SiVEC-IAV™, a pioneering antiviral solution that can be easily inhaled or sprayed to offer rapid and broad protection against the flu. Not only does it work against a wide range of strains, but it's also easy to use, store, and produce. SiVEC encourages everyone to embrace this revolutionary approach to flu treatment and prevention, ensuring a flu season that's more manageable and less threatening.

SiVEC-IAV™ is the first inhaled live biotherapeutic antiviral. SiVEC-IAV is an siRNA therapeutic that is delivered to the respiratory tissues to stop influenza virus infection. The BactPac platform has been engineered to express shRNA molecules targeting conserved regions in all type A influenza viruses, providing fast-acting broad anti-influenza activity against seasonal and pandemic flu.

ADVANTAGES of SiVEC-IAV™

• Inhaled or spray delivery to the respiratory tissues for rapid activity

• Non-invasive, safe and easy to use anytime and anywhere

• Broad protection against a wide range of influenza strains

• Activity against influenza viruses resistant to neuraminidase inhibitors

• Prevents development of antiviral resistance while maximizing protection

• Does not require cold-chain storage, scalable, rapid manufacturing

• Can be used in high-risk patients with complicated influenza